Nuchal Scan for Down’s Syndrome Screening

11-13 weeksAlmost everyone recognises the Nuchal Scan as a screening test for Down’s Syndrome however, the first trimester of your pregnancy should be seen as much more.

All women, whatever their age, carry a risk of delivering a baby with a chromosomal problem; the risk increases as the age of the mother increases. These syndromes are chromosomal abnormalities caused by the presence of an extra chromosome within the cells of the baby. At this is my, we are able to calculate the risk not only for Down’s Syndrome (T21) in the first trimester but also for Edward’s (T18) and Patau’s (T13) Syndromes. In requested cases we can also calculate the risk for Triplody and Turners Syndrome. Trisomy 21 is the most common chromosomal abnormality followed by Trisomy 18, Trisomy 13, Triplody and Turners syndrome.

Nuchal & Down's Syndrome Scan

Nuchal Measurement

Why choose this is my: for your 11 – 13 week pregnancy scan?

Nuchal screening is best performed between 11 weeks and 13 weeks + 6 days but for those women who have missed this time window we are able to offer a second trimester screening test.

Screening at this is my: centres is carried out by highly specialised professionals dedicated to the screening process. Results are produced with increased accuracy that can be far better than any test available via the NHS or other private pregnancy clinics. It is important when choosing a test location to check what screening method is used, what markers are used and what detection and positive rates are quoted.

Why? At this is my we check more of your baby’s anatomy and measure many more markers to calculate risk and assess your baby’s well-being.

Quick Glance Guide & Comparison of Options for Down’s Syndrome & Chromosomal Screening

Make your choice as to which test is best for your pregnancy.

With the introduction of first trimester screening on the NHS many patients are not always informed of the ALL the options available to them for chromosomal screening. Many believe that the test offered by private healthcare providers to be the same as those available via the NHS, this however is not the case.

This information I hope, will highlight the differences between the screening tests and make it easier for everyone to be informed about the available options so they can make the choice about which screening test is best for them and their pregnancy.
At this is my we are a dedicated specialist team, who are passionate about chromosomal screening.

this is my: health screening & ultrasound centre has performed over 34,000 private Nuchal scans and we have a 100% success rate in obtaining the Nuchal measurement.

If your NHS scan fails to obtain the Nuchal measurement, then call the experts for an instant appointment. It is important to be seen, where possible before 14 weeks pregnant.

Our expert service and the quality of care that we offer to our clients is paramount.
Our expertise is reassuring.

this is my: options

Previously when the NHS only offered a second trimester triple or quadruple test the midwife or GP would usually give information about private first trimester screening options as it was seen as a far better test. Nothing has changed! Addmark®, developed by Professor Howard Cuckle, Mr Gerald Mason and his team, is still to this day a far superior test to the NHS combined screening in many ways.

We consistently hear from our clients that their healthcare professional has told them that “the Nuchal test is available on the NHS now”, it is, but patients also assume that it is the same test as the Addmark® – this is not true. Addmark® puts the pregnancy at 6 times less risk of miscarriage from prenatal diagnosis via CVS or amniocentesis than the NHS combined and still out performs it, detecting a greater number of chromosomally affected pregnancies.

For those patients who have missed out on first trimester screening and are more than 14 weeks pregnant then we have a second trimester option which measures the Nuchal fold and Nose Bone length – Genmark™ is the optimal second trimester screen with the highest detection and lowest positive rate.

Below is a quick reference guide to what each test is based on and the detection and positive rates. The optimal test is the one which gives the highest detection for the lowest screen positive rate.

 

1st Trimester Screening
Features
Addmark ® Nuchal + NHS Combined*
One stop service

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Result availability

Immediately or within 3 working days if blood sample taken at the time of the scan

Immediately

Up to 2+ weeks after scan

Gestational age

9 – 13 weeks

11 – 13 weeks

11 – 13 weeks

Maternal blood markers

Up to 8

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2 only

Ultrasound markers

Nuchal Translucency

Nose Bone

Nuchal Translucency

Nose Bone

Ductus Venous

Tricuspid Flow

Nuchal Translucency only

Additional ultrasound markers viewed

but not included in risk calculation

Ductus Venous,

Tricuspid Flow

Intra Cranial Translucency

Intra Cranial Translucency

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Anatomy check

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Ask Your Hospital

Down’s detection rate

93%

89%

Between 75 – 90%

(Ask your hospital)

Chance of high risk result 0.6%

2.8%

2-3%

(Ask your hospital)

Screened chromosomal syndromes

Down’s, Edwards’ & Patau

Down’s, Edwards’ & Patau

Down’s only

Immediate appointment

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Cost for peace of mind

Only £195

Only £100

NHS

*Detection and positive rates taken from current NHS patient leaflet ‘Testing for Down’s syndrome in pregnancy’, May 2010

Addmark® is still the No.1 choice for chromosomal screening

Includes the option to screen for Pre-eclampsia

Why screen for pre-eclampsia?
Pre-eclampsia is pregnancy induced high blood pressure and is dangerous to both mother and baby. The only treatment is delivery and the timing of this has to be balanced against the stage of the pregnancy / maturity of your baby.
Identification of women at high risk allows better monitoring of your pregnancy to identify early clinical signs. If necessary medication can be given to regulate the condition for an improved pregnancy outcome should early delivery be indicated.

Between 11 – 13 weeks 6 days the best test is Addmark® as it detects the highest number of chromosomal affected pregnancies and puts fewer women at risk of an invasive procedure as the positive screen rate is low. For those women who cannot give a blood sample, for whatever reason, then Nuchal+ is the best option.

 

What if I am 14 weeks pregnant or more?

Don’t worry. This is my offers a multi-marker screening test for  patients who have missed the window of opportunity for first trimester nuchal. Genmark™ is the option for you in the second trimester and can be performed up to 20 weeks. Again, it combines ultrasound and blood markers to calculate a risk and again it is better than the second trimester triple or quadruple blood test available via the NHS

With all chromosomal screening tests the growth, well being and anatomy of the baby is checked to give patients reassurance at this early stage that all is well.

If we receive your blood sample a week prior to your pregnancy scan the results from your pregnancy screening test are usually available at the time of the test. If the blood sample is taken after your pregnancy scan, your test results will be available within 3-5 working days

2nd Trimester Screening
Features
Genmark™ NHS quadruple*
One stop service

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No

Result availability

Immediately or within 3 working days if blood sample taken at the time of the scan

Up to 2+ weeks after sample

Gestational age

14 – 20 weeks

14 – 20 weeks

Maternal blood markers

4

4

Ultrasound markers

Nuchal Fold

Nose Bone Length

Additional ultrasound markers viewed

but not included in risk calculation

Foci in the heart

Echogenic Bowel

Renal Dilatation

Long Bone Lengths

Pre Nasal Oedema

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Anatomy check

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Down’s detection rate

80%

75%

(Ask your Hospital)

Chance of high risk result

2.7%

3%

(Ask your Hospital)

Screened chromosomal syndromes

Down’s & Edwards’

Down’s only

Immediate appointment

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Cost for peace of mind

Only £195

NHS

*Detection and positive rates taken from current NHS patient leaflet ‘Testing for Down’s syndrome in pregnancy’, May 2010

How to interpret the screened risk

For Addmark® and Genmark™ screening tests  a risk result between 1:2 and 1:250 is considered to be a high risk. A low risk result less than 1 in 250 does not exclude Down’s Syndrome, but does mean the chance of your baby having Down’s Syndrome is classified as very small.

For Nuchal+ screening a risk result between 1:2 and 1:300 is considered to be high risk. A low risk result less than 1:300 does not exclude Down’s Syndrome, but does mean the chance of your baby having Down’s Syndrome is classified as very small.
Parents will receive full counselling concerning the significance of their risk result and the options available should further testing be required.

It is important to note, that for an increased Nuchal measurement, the option to have a fetal echocardiogram scan (a fetal heart scan) can now be offered privately at Leeds Screening Centre. This would be carried out by our own Paediatric / Fetal Cardiac Consultant who can give detailed information about the health of your baby’s heart as an increased Nuchal measurement can be associated or be a marker for congenital heart defects (CHD).

The only way to know for sure whether the baby has a chromosomal abnormality or not is to have a diagnostic test, either Chorionic Villus Sampling (CVS) or Amniocentesis (Amnio). These tests carry a risk of miscarriage between 1% & 0.7%.

All screening tests give you a risk figure which is further clarified as  a screen positive or screen negative risk or result. The risk figure and its meaning will be discussed with you so that an informed choice can be made. It is important to remember that it is a screening test and does not give a definite yes or no answer. It gives you your chances of the pregnancy being normal or affected. For those who do screen positive or high risk it must be said that the vast majority of those pregnancies will be normal, but that the risk is sufficiently high to warrant or consider a prenatal diagnostic test.

Should you have any questions please do not hesitate to call this is my: and our trained co-coordinators  will be happy to advise you.

Down’s syndrome screening can seem a bit of a ‘minefield’ but we hope to give you the information you require so that you can make the right decision for you and your future.

this is my: Health Screening & Ultrasound Centre Has performed over 34000 first trimester screens to date.

 

Should every mother have the test that could eliminate Down’s Syndrome?

Read more from the Daily Mail : HERE>

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